AdventHealth Translational Research Institute, Orlando, FL, United States of America. Electronic address: D2d@tuftsmedicalcenter.org. Tufts Medical Center, Boston, MA, United States of America. The University of Nebraska Medical Center and Omaha Veterans Affairs Medical Center, Omaha, NE, United States of America. University of Kansas Medical Center, Kansas City, KS, United States of America. Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, and Medical Research Center, University of Oulu and Oulu University Hospital, 90220 Oulu, Finland; Department of Pediatric Gastroenterology and Metabolic Diseases, Pediatric Institute, Poznan University of Medical Sciences, 60-572 Poznań, Poland. Weill Cornell Medicine, New York, NY, United States of America. Stanford University Medical Center, Stanford, CA, United States of America. The University of Colorado School of Medicine, Aurora, CO, United States of America; The Veterans Affairs Eastern Colorado Health Care System, Aurora, CO, United States of America. National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, United States of America.